Asterisk as PBX 8x50

I need to replace an old Mitel SX50, can Asterisk handle 8 trunk line with 50 analog ext.?
Can one computer handle two or more TDM2400P cards and has it work as one PBX?
Or If I build two or more computer each with one TDM2400P card, can I cluster them as one PBX?

Any suggestions?