for sure, all config is organized in database, and managed via GUI - but this is WEB development question, outside of this forum ( Just can say - that I’ve used a free edition of Isomorphic Software: “SmartClient Ajax RIA System”)
Asterisk has great feature - dynamic dialplan, it is stored and managed in database. You do not need to “reload” each time you do changes, same is for sippeers (check the wiki)