Telnet xx.2xx.x.1xx 5060 ....connection refused

telnet x0.xx9.5.xxx 5060
Trying x0.xx9.5.xxx
telnet: connect to address x0.xx9.5.xxx: Connection refused

How can I open the 5060 port?

dnsmasq 1343 nobody 5u IPv4 10370 0t0 TCP *:domain (LISTEN)
dnsmasq 1343 nobody 7u IPv6 10372 0t0 TCP *:domain (LISTEN)
mysqld 1529 mysql 10u IPv4 11196 0t0 TCP localhost:mysql (LISTEN)
master 1621 root 12u IPv4 11414 0t0 TCP localhost:smtp (LISTEN)
master 1621 root 13u IPv6 11416 0t0 TCP localhost:smtp (LISTEN)
sshd 2858 root 3u IPv4 19986 0t0 TCP *:ssh (LISTEN)
sshd 2858 root 4u IPv6 19988 0t0 TCP *:ssh (LISTEN)
node 21086 asterisk 14u IPv4 621391 0t0 TCP *:vcom-tunnel (LISTEN)
asterisk 21138 asterisk 8u IPv4 621269 0t0 TCP *:radan-http (LISTEN)
asterisk 21138 asterisk 9u IPv4 621385 0t0 TCP *:5038 (LISTEN)
httpd 21521 root 4u IPv6 624371 0t0 TCP *:xfer (LISTEN)
httpd 21521 root 6u IPv6 624376 0t0 TCP *:ctf (LISTEN)
httpd 21521 root 8u IPv6 624381 0t0 TCP *:85 (LISTEN)
httpd 21521 root 10u IPv6 624386 0t0 TCP *:81 (LISTEN)
httpd 21521 root 12u IPv6 624391 0t0 TCP *:http (LISTEN)
httpd 21521 root 14u IPv6 624396 0t0 TCP *:mit-ml-dev (LISTEN)
httpd 21523 asterisk 4u IPv6 624371 0t0 TCP *:xfer (LISTEN)
httpd 21523 asterisk 6u IPv6 624376 0t0 TCP *:ctf (LISTEN)
httpd 21523 asterisk 8u IPv6 624381 0t0 TCP *:85 (LISTEN)
httpd 21523 asterisk 10u IPv6 624386 0t0 TCP *:81 (LISTEN)
httpd 21523 asterisk 12u IPv6 624391 0t0 TCP *:http (LISTEN)
httpd 21523 asterisk 14u IPv6 624396 0t0 TCP *:mit-ml-dev (LISTEN)
httpd 21524 asterisk 4u IPv6 624371 0t0 TCP *:xfer (LISTEN)
httpd 21524 asterisk 6u IPv6 624376 0t0 TCP *:ctf (LISTEN)
httpd 21524 asterisk 8u IPv6 624381 0t0 TCP *:85 (LISTEN)
httpd 21524 asterisk 10u IPv6 624386 0t0 TCP *:81 (LISTEN)
httpd 21524 asterisk 12u IPv6 624391 0t0 TCP *:http (LISTEN)
httpd 21524 asterisk 14u IPv6 624396 0t0 TCP *:mit-ml-dev (LISTEN)
httpd 21525 asterisk 4u IPv6 624371 0t0 TCP *:xfer (LISTEN)
httpd 21525 asterisk 6u IPv6 624376 0t0 TCP *:ctf (LISTEN)
httpd 21525 asterisk 8u IPv6 624381 0t0 TCP *:85 (LISTEN)
httpd 21525 asterisk 10u IPv6 624386 0t0 TCP *:81 (LISTEN)
httpd 21525 asterisk 12u IPv6 624391 0t0 TCP *:http (LISTEN)
httpd 21525 asterisk 14u IPv6 624396 0t0 TCP *:mit-ml-dev (LISTEN)
httpd 21526 asterisk 4u IPv6 624371 0t0 TCP *:xfer (LISTEN)
httpd 21526 asterisk 6u IPv6 624376 0t0 TCP *:ctf (LISTEN)
httpd 21526 asterisk 8u IPv6 624381 0t0 TCP *:85 (LISTEN)
httpd 21526 asterisk 10u IPv6 624386 0t0 TCP *:81 (LISTEN)
httpd 21526 asterisk 12u IPv6 624391 0t0 TCP *:http (LISTEN)
httpd 21526 asterisk 14u IPv6 624396 0t0 TCP *:mit-ml-dev (LISTEN)
httpd 21527 asterisk 4u IPv6 624371 0t0 TCP *:xfer (LISTEN)
httpd 21527 asterisk 6u IPv6 624376 0t0 TCP *:ctf (LISTEN)
httpd 21527 asterisk 8u IPv6 624381 0t0 TCP *:85 (LISTEN)
httpd 21527 asterisk 10u IPv6 624386 0t0 TCP *:81 (LISTEN)
httpd 21527 asterisk 12u IPv6 624391 0t0 TCP *:http (LISTEN)
httpd 21527 asterisk 14u IPv6 624396 0t0 TCP *:mit-ml-dev (LISTEN)
httpd 21528 asterisk 4u IPv6 624371 0t0 TCP *:xfer (LISTEN)
httpd 21528 asterisk 6u IPv6 624376 0t0 TCP *:ctf (LISTEN)
httpd 21528 asterisk 8u IPv6 624381 0t0 TCP *:85 (LISTEN)
httpd 21528 asterisk 10u IPv6 624386 0t0 TCP *:81 (LISTEN)
httpd 21528 asterisk 12u IPv6 624391 0t0 TCP *:http (LISTEN)
httpd 21528 asterisk 14u IPv6 624396 0t0 TCP *:mit-ml-dev (LISTEN)
httpd 21529 asterisk 4u IPv6 624371 0t0 TCP *:xfer (LISTEN)
httpd 21529 asterisk 6u IPv6 624376 0t0 TCP *:ctf (LISTEN)
httpd 21529 asterisk 8u IPv6 624381 0t0 TCP *:85 (LISTEN)
httpd 21529 asterisk 10u IPv6 624386 0t0 TCP *:81 (LISTEN)
httpd 21529 asterisk 12u IPv6 624391 0t0 TCP *:http (LISTEN)
httpd 21529 asterisk 14u IPv6 624396 0t0 TCP *:mit-ml-dev (LISTEN)
httpd 21530 asterisk 4u IPv6 624371 0t0 TCP *:xfer (LISTEN)
httpd 21530 asterisk 6u IPv6 624376 0t0 TCP *:ctf (LISTEN)
httpd 21530 asterisk 8u IPv6 624381 0t0 TCP *:85 (LISTEN)
httpd 21530 asterisk 10u IPv6 624386 0t0 TCP *:81 (LISTEN)
httpd 21530 asterisk 12u IPv6 624391 0t0 TCP *:http (LISTEN)
httpd 21530 asterisk 14u IPv6 624396 0t0 TCP *:mit-ml-dev (LISTEN)
httpd 21568 asterisk 4u IPv6 624371 0t0 TCP *:xfer (LISTEN)
httpd 21568 asterisk 6u IPv6 624376 0t0 TCP *:ctf (LISTEN)
httpd 21568 asterisk 8u IPv6 624381 0t0 TCP *:85 (LISTEN)
httpd 21568 asterisk 10u IPv6 624386 0t0 TCP *:81 (LISTEN)
httpd 21568 asterisk 12u IPv6 624391 0t0 TCP *:http (LISTEN)
httpd 21568 asterisk 14u IPv6 624396 0t0 TCP *:mit-ml-dev (LISTEN)
httpd 21646 asterisk 4u IPv6 624371 0t0 TCP *:xfer (LISTEN)
httpd 21646 asterisk 6u IPv6 624376 0t0 TCP *:ctf (LISTEN)
httpd 21646 asterisk 8u IPv6 624381 0t0 TCP *:85 (LISTEN)
httpd 21646 asterisk 10u IPv6 624386 0t0 TCP *:81 (LISTEN)
httpd 21646 asterisk 12u IPv6 624391 0t0 TCP *:http (LISTEN)
httpd 21646 asterisk 14u IPv6 624396 0t0 TCP *:mit-ml-dev (LISTEN)

Perhaps you’ve got Asterisk configured only for UDP-based SIP signaling on 5060? Telnet works over TCP.

netstat -apn | grep -i asterisk or could be netstat -apn | grep -i 5060

for check if port is open could be like this nc -uv 64.21.13.41 5060

Connection to 64.21.13.41 5060 port [udp/sip] succeeded!