Sip gone unreachable on sipml5 page load

I have installed and configure asterisk on my server, everything is working fine, but the problem is when user connected first time following message appears on sip debug :

[May 27 22:13:25] WARNING[20193]: chan_sip.c:3727 __sip_xmit: sip_xmit of 0x7f16b400bdb0 (len 646) to returned -1: No such file or directory
Scheduling destruction of SIP dialog ‘32729691-cce2-c278-d528-924721cfddca’ in 32000 ms (Method: REGISTER)

but on refreshing page sip peer is reachable.